The group of articles and book reviews in this year’s last issue of Sexuality, Health, and Society - Latin American Journal explore different dimensions of sexuality in remarkably diverse social contexts––thus mirroring the social diversity that characterizes the region. We have important contributions for a reflection on the main devices that institute and regulate identities, desires and sexual prac- tices, either in the realm of public health policy, of medical theories, or in communication media. The texts published in this issue shed light on them, addressing their historical singularity and exploring their local articulation.